Cyclobenzaprine: short-term muscle relaxant, side effects and safety

This is a prescription medicine. Only take it if it has been prescribed for you after a medical assessment, and follow your doctor’s and pharmacist’s instructions.

Cyclobenzaprine (Flexeril, Amrix) is a muscle relaxant used alongside rest and physical therapy for short-term muscle spasm from strains and sprains.

Short-term use only

It’s meant for 2 to 3 weeks; there’s little evidence it helps beyond that. The schedule depends on whether you receive immediate-release tablets or extended-release capsules. Follow the prescription for your specific formulation.

Side effects

  • Drowsiness, dizziness: don’t drive until you know how it affects you
  • Dry mouth
  • Constipation
  • Confusion, especially in older adults (often avoided over 65)

Who should avoid it

  • Recent heart attack, heart rhythm problems, heart failure, overactive thyroid
  • Tell the prescriber about glaucoma or difficulty urinating; these conditions need particular caution.
  • Taking MAO inhibitors now or within the past 14 days

Interactions

  • Alcohol, opioids, sleeping pills
  • SSRIs, SNRIs, tramadol, bupropion (serotonin syndrome risk)

Frequently asked questions

Is cyclobenzaprine addictive?

It isn’t a controlled substance, but it’s sedating and should be used short-term.

    Ask a pharmacist

    Questions about a product, dosage or delivery? Leave your details and our team will get back to you within 1 business day.

    General information only. It isn’t a substitute for advice from your doctor or pharmacist.

    Source and further reading

    MedlinePlus patient medicine information. This overview does not list every warning or interaction; read the leaflet supplied with your medicine.

    Gabapentin: nerve pain, side effects and misuse risk

    This is a prescription medicine. Only take it if it has been prescribed for you after a medical assessment, and follow your doctor’s and pharmacist’s instructions.

    Gabapentin (Neurontin) is used for nerve pain after shingles (postherpetic neuralgia) and for some types of seizures. It’s also often used off-label for other nerve pain.

    How it’s taken

    The dose starts low and is increased over days to weeks to limit side effects, usually split into 3 doses a day. Lower doses are needed with kidney problems.

    Side effects

    • Dizziness and drowsiness
    • Unsteadiness, falls in older adults
    • Swelling of hands and feet
    • Blurred vision
    • Weight gain

    Serious warnings

    • Breathing problems when combined with opioids, sedatives or alcohol, or in people with lung disease
    • Mood changes or suicidal thoughts: seek urgent medical help; use emergency services if there is immediate danger
    • Can be misused; tell your doctor about any history of substance use
    • Rare severe allergic reactions

    Stopping

    Don’t stop suddenly, especially if used for seizures; your doctor will taper over at least a week.

    Frequently asked questions

    Is gabapentin a painkiller?

    It calms overactive nerves rather than acting like typical pain relievers.

      Ask a pharmacist

      Questions about a product, dosage or delivery? Leave your details and our team will get back to you within 1 business day.

      General information only. It isn’t a substitute for advice from your doctor or pharmacist.

      Source and further reading

      MedlinePlus patient medicine information. This overview does not list every warning or interaction; read the leaflet supplied with your medicine.

      Montelukast (Singulair): asthma, allergies and the mental health warning

      This is a prescription medicine. Only take it if it has been prescribed for you after a medical assessment, and follow your doctor’s and pharmacist’s instructions.

      Montelukast (Singulair) is a once-daily tablet that blocks leukotrienes, chemicals that narrow airways and trigger allergy symptoms. It’s used to prevent asthma symptoms and exercise-induced bronchospasm, and sometimes for allergies.

      Not a rescue medicine

      Montelukast won’t relieve a sudden asthma attack. Always carry your rescue inhaler.

      Side effects

      • Headache
      • Stomach upset
      • Upper respiratory infections

      FDA boxed warning: mood and behavior

      Montelukast can cause serious neuropsychiatric effects in some people, including agitation, nightmares, sleep problems, depression and suicidal thoughts. Because of this, it isn’t a first-choice treatment for mild allergies. Stop and contact your doctor right away if you or your child notice these changes. Seek emergency help if there is an immediate risk of harm.

      Frequently asked questions

      When should montelukast be taken?

      Usually in the evening for asthma; for exercise-induced symptoms, at least 2 hours before exercise if not already taking it daily.

        Ask a pharmacist

        Questions about a product, dosage or delivery? Leave your details and our team will get back to you within 1 business day.

        General information only. It isn’t a substitute for advice from your doctor or pharmacist.

        Source and further reading

        MedlinePlus patient medicine information. This overview does not list every warning or interaction; read the leaflet supplied with your medicine.

        Calorie Deficit for Weight Loss: How Many Calories Should You Eat?

        By the Medsmingle Team · Updated 11 November 2026

        To lose weight, you need to take in fewer calories than your body burns. This is called a calorie deficit. Your calorie needs depend on your size, health, age and activity. A clinician or registered dietitian can help set an appropriate goal; gradual weight loss is generally more sustainable than a crash diet.

        What is a calorie deficit?

        Your body burns calories all day, both to keep you alive and to fuel movement. When you take in fewer calories than you burn, your body uses its stored energy to make up the difference, and you lose weight. You can create a deficit by eating less, moving more, or both.

        How many calories do you burn?

        It depends on your age, sex, size and how active you are. These US government estimates show roughly how many calories adults need each day to stay at the same weight:

        Age and activityWomen (calories a day)Men (calories a day)
        19 to 60, not active1,600 to 2,0002,200 to 2,600
        19 to 60, active2,200 to 2,4002,600 to 3,000
        61 and over, not active1,6002,000
        61 and over, active2,0002,400 to 2,600

        For a personal estimate, try the NIH Body Weight Planner. It makes a calorie and activity plan to reach a goal weight by a set date, and to keep it off afterwards.

        How big should your calorie deficit be?

        There is no calorie target that is right for everyone. Choose a balanced eating plan and a manageable change in activity with your healthcare professional. Do not use a very low-calorie diet without medical supervision. Get individual advice if you are pregnant, breastfeeding, under 18, take diabetes medicines, or have a history of an eating disorder.

        Why “3,500 calories = 1 pound” doesn’t hold up

        You may have read that cutting 3,500 calories loses a pound, so a 500-calorie daily deficit loses exactly a pound a week. NIH researchers have shown this rule overestimates weight loss because it ignores how your body changes as you lose weight. As you get lighter, you burn fewer calories, so the same eating plan gives a smaller deficit and weight loss slows.

        That’s normal, not failure. Re-check your calorie needs as your weight changes. If your weight has stopped moving for several weeks, read our guide to the weight-loss plateau.

        How to cut calories without feeling starved

        • Keep a food diary for a week or two. It shows where small changes would make the biggest difference. Count drinks, alcohol, cooking oils, toppings and sauces too.
        • Check labels and portions. Weighing food, at least at first, makes your estimates more accurate.
        • Build meals around protein, vegetables and fiber. They help you feel full on fewer calories; see how much protein for weight loss you need.
        • Move more. Regular physical activity is one of the CDC’s steps for losing weight, and it burns extra calories. Walking is an easy place to start.
        • Sleep and manage stress. The CDC includes enough sleep and stress management in its steps for losing weight.

        What results to expect

        Even a modest loss helps. According to US guidelines, losing 3% to 5% of your body weight brings real health benefits, and losing more than 5% can further improve blood pressure and cholesterol. For someone who weighs 200 pounds, 5% is 10 pounds.

        If you have a lot of weight to lose, structured support helps. Guidelines recommend a comprehensive lifestyle program lasting at least 6 months. A doctor can also tell you whether other treatments might suit you.

        Frequently asked questions

        Is 1,200 calories a day right for everyone?

        No. It can be too little for many people. Your needs and an appropriate deficit should be assessed individually.

        Why have I stopped losing weight?

        As you lose weight, your body burns fewer calories, so the deficit you started with shrinks. Re-check your numbers, and look at your activity, sleep and portion sizes.

        Should I cut calories or exercise more?

        Both help. The CDC recommends combining healthy eating with regular physical activity, rather than relying on one alone.

        Sources

        This article is for general information only and isn’t a substitute for advice from a doctor or pharmacist. Don’t start, stop or change a medicine without talking to a qualified healthcare professional.

        Erectile Dysfunction (ED): Causes, Treatment and When to See a Doctor

        By the Medsmingle Team · Updated 11 November 2026

        Erectile dysfunction (ED) means you can’t get or keep an erection firm enough for sex. It’s common, especially as men get older, and it can usually be treated. Because ED can be an early sign of heart disease, diabetes or another health problem, see a doctor if it keeps happening.

        What is erectile dysfunction?

        ED is trouble getting an erection, keeping it long enough for sex, or both. It used to be called impotence. Between 30 million and 50 million men in the US have ED. About 40% of men are affected at age 40 and about 70% by age 70, but ED isn’t a routine part of aging.

        Occasional problems are normal. Most men sometimes can’t get or keep an erection, usually because of stress, tiredness or heavy drinking. It’s worth looking into when it keeps happening.

        What causes ED?

        An erection depends on healthy blood vessels, nerves and hormones, so anything that affects them can cause ED:

        • Health conditions: diabetes, heart and blood vessel disease (including atherosclerosis and high blood pressure), stroke, chronic kidney disease, obesity, low testosterone, thyroid problems, multiple sclerosis, spinal cord injury, pelvic surgery, Peyronie’s disease.
        • Medicines: some antidepressants, blood pressure medicines and diuretics, antihistamines, appetite suppressants, pain relievers, sedatives, ulcer medicines, and chemotherapy or hormone medicines.
        • Mind and mood: anxiety, depression, stress, low self-esteem and worry about sex.
        • Lifestyle: smoking, drinking too much alcohol, using recreational drugs and not getting enough physical activity.

        Why ED can be a warning sign for your heart

        The American Urological Association advises that men be told ED is a risk marker for underlying cardiovascular disease. Conditions that damage blood vessels, such as atherosclerosis, can reduce blood flow to the penis as well as to the heart. ED that keeps happening is a good reason to get your blood pressure, cholesterol and blood sugar checked.

        How is ED diagnosed?

        A doctor will ask about your symptoms, health, medicines and lifestyle, and examine you. Blood tests can look for diabetes, high cholesterol and hormone problems, and US guidelines recommend measuring testosterone in men with ED. You may also be asked about your mood and relationship, because these often play a part.

        How is ED treated?

        Treatment starts with the cause, where one is found. Choosing a treatment is personal, and many couples decide together.

        Lifestyle changes

        Stopping smoking, cutting down on alcohol, avoiding recreational drugs, keeping to a healthy weight, eating well and staying active can prevent or improve ED. Aim for at least 150 minutes of moderate activity a week. Ask your healthcare professional about a suitable weight-management plan.

        Counseling

        If stress, anxiety, depression or relationship problems are involved, counseling can ease anxiety about sex. A partner can join the sessions.

        Reviewing your medicines

        If a medicine may be causing ED, your doctor may lower the dose or switch you to another one. Don’t stop a medicine on your own.

        Prescription tablets

        The most common treatment is a PDE5 inhibitor: sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) or avanafil (Stendra). These medicines improve blood flow to the penis, but only during sexual stimulation. They don’t increase desire and they don’t cure ED. A doctor decides whether one is safe for you and at what dose.

        Important safety information: never take these medicines if you use nitrate medicines for chest pain, such as nitroglycerin, or recreational nitrites known as “poppers.” Do not combine them with riociguat. Get medical help right away for an erection that lasts longer than 4 hours, sudden loss of vision or hearing, or chest pain during sex.

        Other treatments

        • Vacuum devices: a tube and pump draw blood into the penis, and an elastic ring helps keep the erection.
        • Injections or urethral suppositories: medicine that causes an erection, used in or on the penis. A doctor shows you how.
        • Testosterone: for men who have both ED and low testosterone.
        • Surgery: usually a penile implant, considered when other treatments haven’t worked.

        Talk to a professional before taking ED medicine

        ED medicines can interact with other medicines and cause serious side effects. Don’t order ED medicine online without talking to a doctor or pharmacist first. Tell them about everything you take, including over-the-counter medicines, vitamins, supplements and herbal products.

        When to see a doctor

        • Erection problems keep happening.
        • You’re worried ED could be linked to another health problem, such as diabetes or heart disease.
        • Get help right away for an erection that lasts longer than 4 hours.

        Frequently asked questions

        Is ED a normal part of getting older?

        No. ED becomes more common with age, but it isn’t a routine part of aging, and it can often be treated.

        Can stress cause ED?

        Yes. Stress, anxiety and depression can cause ED or make it worse. Counseling can help.

        Can ED be cured?

        Sometimes. If the cause can be treated, such as a medicine, a lifestyle habit or anxiety, erections may come back. ED tablets help you get an erection but don’t treat the underlying cause.

        Does losing weight help ED?

        It can. Obesity is one cause of ED, and keeping to a healthy weight, staying active and not smoking may prevent or improve it.

        Do ED tablets work without arousal?

        No. They help blood flow to the penis only during sexual stimulation, and they don’t increase desire.

        Reading medicine listings

        If your prescriber recommends treatment, learn the difference between medicine strength and pack size before comparing listings. A listed strength is not a personal dose recommendation.

        Sources

        This article is for general information only and isn’t a substitute for advice from a doctor or pharmacist. Don’t start, stop or change a medicine without talking to a qualified healthcare professional.

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