By the Medsmingle Team · Updated 13 November 2026
This is a prescription medicine. Only take it if it has been prescribed for you, and follow your doctor’s and pharmacist’s instructions.
Prednisone is a corticosteroid that calms inflammation and the immune system. It’s used for asthma flare-ups, severe allergies, arthritis, skin conditions and many other illnesses, with treatment duration depending on the condition.
How to take it
- Take it in the morning with food to reduce stomach upset and trouble sleeping
- Follow the schedule exactly, especially if the dose steps down
Common short-course side effects
- Increased appetite
- Trouble sleeping, restlessness
- Mood changes: irritability, feeling “wired” or low
- Higher blood sugar, which matters if you have diabetes
- Stomach upset, heartburn
With longer use
Weeks to months of prednisone can cause weight gain, raised blood pressure, thinning bones, cataracts, easy bruising and a higher risk of infection. Your doctor will balance benefits and risks and may recommend calcium, vitamin D or bone protection.
Don’t stop suddenly after long use
The need for a taper depends on the dose, duration, repeated courses and your medical history. Follow the prescribed stopping plan, even for a short course; do not decide on a taper yourself.
Call your doctor if you have
- Signs of infection: fever, chills, sore throat
- Very high blood sugar readings, extreme thirst
- Black or bloody stools, or vomiting blood
- Severe mood changes or confusion
- Vision changes
Interactions
NSAIDs such as ibuprofen raise the risk of stomach bleeding. Tell your doctor about diabetes medicines, blood thinners and live vaccines.
Frequently asked questions
How quickly does prednisone work?
Often within hours to a day or two for inflammation and breathing problems.
Can I drink alcohol on prednisone?
It’s best to limit alcohol, which adds to stomach irritation.
For questions about a prescription or symptoms, speak with your own doctor or pharmacist. For website enquiries, contact our team.
About Medsmingle
Medsmingle (medsmingle.com) shares clear, plain-English information on medicines and everyday health. Explore more health guides and the latest articles, read about us, or contact our team with a question.
This article is for general information only and isn’t a substitute for advice from a doctor or pharmacist.
Source and further reading
MedlinePlus patient medicine information. This overview does not list every warning or interaction.
