Amoxicillin vs Augmentin: what’s the difference?

By the Medsmingle Team · Updated 13 November 2026

This is a prescription medicine. Only take it if it has been prescribed for you, and follow your doctor’s and pharmacist’s instructions.

Amoxicillin and Augmentin are related penicillin antibiotics. Augmentin is amoxicillin combined with clavulanic acid, which stops some bacteria from breaking the antibiotic down.

The difference

• Amoxicillin treats many common infections: strep throat, ear infections, some sinus and chest infections, and some urinary infections.
• Augmentin covers extra bacteria that resist amoxicillin alone, so it’s often used for bites, more stubborn sinus or ear infections and some skin infections.

Your doctor chooses based on the likely bacteria. A broader antibiotic isn’t automatically better; using the narrowest effective one helps prevent resistance.

Side effects

• Diarrhea, nausea or upset stomach, more common with Augmentin
• Yeast infections (thrush)
• Rash

Taking Augmentin with food reduces stomach upset.

Penicillin allergy: get urgent help

Stop and call 911 for swelling of the face or throat, trouble breathing, or hives with dizziness. Tell your doctor about any previous reaction to penicillin. Many people labeled allergic aren’t, and an allergist can test this.

Call your doctor if you have

• Severe or watery diarrhea, especially with blood or cramps, during or after the course (possible C. diff infection)
• A blistering or peeling rash
• Yellow skin or eyes
• No improvement after 2 to 3 days

Tips

• Finish the course as prescribed unless your doctor tells you otherwise
• Never share antibiotics or use leftovers
• Antibiotics do not treat colds or flu

Frequently asked questions

Is Augmentin stronger than amoxicillin?

It works against more types of bacteria, but that doesn’t make it the better choice for every infection.

Can I drink alcohol with amoxicillin?

Ask your pharmacist about your prescription and health conditions. Alcohol may worsen side effects or make you feel more unwell.

For questions about a prescription or symptoms, speak with your own doctor or pharmacist. For website enquiries, contact our team.

This article is for general information only and isn’t a substitute for advice from a doctor or pharmacist.

Source and further reading

MedlinePlus patient medicine information. This overview does not list every warning or interaction.