By the Medsmingle Team · Updated 13 November 2026
This is a prescription medicine. Only take it if it has been prescribed for you, and follow your doctor’s and pharmacist’s instructions.
Amlodipine is a calcium channel blocker used for high blood pressure and some types of chest pain (angina). It’s taken once a day and is one of the most prescribed medicines in the US.
How it works
It relaxes the muscles in blood vessel walls, so blood flows more easily and blood pressure falls.
Common side effects
- Swollen ankles or feet, more common at higher doses
- Flushing or feeling warm
- Headache and dizziness
- Tiredness
- Palpitations
Amlodipine can cause ankle swelling, but new swelling can also have other causes and should not be self-diagnosed. Seek urgent help if it comes with breathlessness or chest pain. Tell your doctor if it bothers you, as a lower dose or different medicine may help.
Get medical help if you have
- Chest pain that’s new or worse
- Fainting or a very fast or irregular heartbeat
- Yellow skin or eyes
- Swelling of the face, lips or throat
Interactions
- Grapefruit in large amounts can raise levels slightly
- Simvastatin: doses above 20 mg aren’t recommended with amlodipine
- Some antifungals and antibiotics (such as clarithromycin) can increase its effect
- Always tell your pharmacist about all your medicines and supplements
Frequently asked questions
How long does amlodipine take to work?
Blood pressure starts to fall within days, with the full effect after about 1 to 2 weeks.
Can I stop amlodipine suddenly?
Don’t stop without talking to your doctor; your blood pressure may rise.
For questions about a prescription or symptoms, speak with your own doctor or pharmacist. For website enquiries, contact our team.
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Medsmingle (medsmingle.com) shares clear, plain-English information on medicines and everyday health. Explore more health guides and the latest articles, read about us, or contact our team with a question.
This article is for general information only and isn’t a substitute for advice from a doctor or pharmacist.
Source and further reading
MedlinePlus patient medicine information. Read the leaflet for your specific medicine; this overview does not list every warning or interaction.
